Propargyl-PEG6-acid
Based on 1 Customer Validation
Propargyl-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG6-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- CAS No.: 1951438-84-8
- Formule: C16H28O8
- Masse moléculaire:348.39
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-118764
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Propargyl-PEG5-acidADC Linker -
HY-130481
Propargyl-PEG4-acidPROTAC Linker -
HY-130379
Propargyl-PEG8-acidADC/PROTAC Linker -
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Propargyl-PEG1-acidPROTAC Linkers -
HY-101157R
Propargyl-PEG5-acid (Standard)ADC Linker -
HY-126975
Propargyl-PEG3-acidADC/PROTAC Linker -
HY-140020
Propargyl-PEG10-acidPEG Derivative -
HY-130383
Propargyl-PEG7-acidADC/PROTAC Linker -
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Propargyl-PEG1-NHS esterADC Linkers -
HY-114670
Propargyl-PEG4-aminePROTAC Linker
Voir tous les produits spécifiques à Isoform ADC Linkers
MoreVoir tous les produits spécifiques à Isoform PROTAC Linkers
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Activité biologique
Description
IC50 & Target
[1]|
Cleavable Linker |
PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1951438-84-8
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Appearance Liquid (Density: 1.126 g/cm3)
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Masse moléculaire 348.39
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Formule C16H28O8
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Color Colorless to light yellow
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SMILES
C#CCOCCOCCOCCOCCOCCOCCC(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocole
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Pureté et documentation
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Fiche technique (261 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Propargyl-PEG6-acid Related Classifications
HY-130386 Related Classifications
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