ALK
ALK (anaplastic lymphoma kinase) is a receptor tyrosine kinase family that in humans contains ALK and its close relative LTK. ALK is a single-pass receptor with a large extracellular segment rich in glycine and MAM domains and an intracellular kinase domain. Its activating ligands belong to the ALKAL family. Physiologically ALK regulates nervous system development, including sympathetic neuron and neuromuscular junction formation. ALK is a major cancer gene: chromosomal rearrangements such as EML4-ALK define a lung adenocarcinoma subtype, ALK fusions occur in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumors, and activating point mutations arise in neuroblastoma. ALK inhibitors, including crizotinib, alectinib and lorlatinib, deliver durable responses in ALK-driven cancers.
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ALK Protéines Recombinantes (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
