(Rac)-DIOA
(Rac)-DIOA ((Rac)-[(Dihydroindenyl) oxy]acetic acid) is the racemate of DIOA (HY-137148), which inhibits acid-sensitive outwardly rectifying (ASOR) and volume-sensitive outwardly rectifying (VSOR) anion channel currents, and classically inhibits K+-Cl- cotransporters (KCC). (Rac)-DIOA can be used to study mechanisms related to ischemic cerebrovascular disease, neurological diseases, tumor acidosis microenvironment, and cell volume disorders.
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- CAS No.: 81166-34-9
- Formule: C20H24Cl2O4
- Masse moléculaire:399.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 81166-34-9
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Masse moléculaire 399.31
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Formule C20H24Cl2O4
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SMILES
O=C(COC1=C(Cl)C(Cl)=C(C(C(CCCC)(C2CCCC2)C3)=O)C3=C1)O
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Synonyms
(Rac)-[(Dihydroindenyl)oxy]acetic acid
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sato-Numata K, et al. Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel. Pflugers Archiv : European journal of physiology. 2016 May;468(5):795-803. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-DIOA Related Classifications
HY-137148A Related Classifications
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