rac-Olodanrigan
rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve.
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- CAS No.: 152362-51-1
- Formule: C32H29NO5
- Masse moléculaire:507.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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AT2 Receptor 75.2 nM (IC50) |
AT1 Receptor 2918 nM (IC50) |
Chemical Information
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CAS No. 152362-51-1
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Masse moléculaire 507.58
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Formule C32H29NO5
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SMILES
O=C(C1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O
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Synonyms
rac-EMA401; rac-PD-126055; EMA400
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
rac-Olodanrigan Related Classifications
HY-19202 Related Classifications
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