RC98
RC98 is a monoclonal antibody targeting programmed cell death ligand 1 (PD-L1) and acts as a selective PD-L1 inhibitor. RC98 binds specifically to human and cynomolgus monkey PD-L1. RC98 blocks the interaction between PD-L1 and its receptor PD-1 to reverse T-cell inactivation mediated by PD-1/PD-L1 signaling. RC98 enhances the cytotoxic T-lymphocyte-mediated anti-tumor immune response against PD-L1-expressing tumor cells. RC98 can be used for the research of tumor immunity and solid tumors.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Species Reactivity
Human
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cynomolgus monkeys (half female and half male)[1]
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Dosage:15 mg/kg
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Administration:i.v.; once weekly; 4 weeks
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Result:Reached a mean peak PD-L1 receptor occupancy of 64.5% on CD3+ T cells within 24 h after the first infusion.
Showed reduced receptor occupancy after repeated dosing but maintained levels above background throughout testing.
Elevated anti-KLH IgM levels versus controls at 168 h, 336 h, and 504 h post-first dose.
Increased anti-KLH IgG levels versus controls at multiple time points post-first and last doses.
Induced sustained elevation of soluble PD-L1 with a strong correlation to serum RC98 concentrations.
Gene ID
Accession
Target
B7-H1/PD-L1/CD274
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RC98 Related Classifications
HY-P992448 Related Classifications
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