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Cat. No.: HY-117021

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RO 5073012

RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a K_i of 6 nM for hTAAR1 and EC₅₀ values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia.

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CAS No.: 1020814-70-3
Formule: C₁₃H₁₆ClN₃
Masse moléculaire:249.74

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RO 5073012 Chemical Structure

CAS No.: 1020814-70-3

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Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

hTAAR1

6 nM (Ki)

mTAAR1

23 nM (EC₅₀)

rTAAR1

25 nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	23 nM Compound: 24, Ro-5073012	Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]
HEK293	EC₅₀	23 nM Compound: 24, Ro-5073012	Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]
HEK293	EC₅₀	25 nM Compound: 24, Ro-5073012	Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]

Chemical Information

CAS No. 1020814-70-3
Masse moléculaire 249.74
Formule C₁₃H₁₆ClN₃
SMILES

CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Galley G, et al. Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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