Robustaflavone
Based on 1 Customer Validation
Robustaflavone is a biflavonoid isolated from Doradilla that has natriuretic properties.
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- Pureté: 99.22%
- CAS No.: 49620-13-5
- Formule: C30H18O10
- Masse moléculaire:538.46
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
21.38 μM
Compound: 7
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29921475] |
| Calu-1 | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against human Calu1 cells after 3 days
Cytotoxicity against human Calu1 cells after 3 days
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[PMID: 10843573] |
| HeLa | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against human HeLa cells after 3 days
Cytotoxicity against human HeLa cells after 3 days
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[PMID: 10843573] |
| HepG2 | EC50 |
0.25 μM
Compound: Robustaflavone (RF)
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Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
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10.1016/S0960-894X(97)00422-8 |
| HepG2 | IC50 |
19.15 μM
Compound: 7
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29921475] |
| HepG2 | IC50 |
337 μM
Compound: Robustaflavone (RF)
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Cytotoxicity towards human hepatoblastoma cell line (2.2.15 cells) measured by inhibition of neutral red dye uptake in vitro
Cytotoxicity towards human hepatoblastoma cell line (2.2.15 cells) measured by inhibition of neutral red dye uptake in vitro
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10.1016/S0960-894X(97)00422-8 |
| K562 | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against human K562 cells after 3 days
Cytotoxicity against human K562 cells after 3 days
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[PMID: 10843573] |
| MGC-803 | IC50 |
15.57 μM
Compound: 7
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Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29921475] |
| Neutrophil | IC50 |
0.45 μM
Compound: 6
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
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[PMID: 29381070] |
| Neutrophil | IC50 |
1.01 μM
Compound: 6
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Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
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[PMID: 29381070] |
| PBMC | IC50 |
77 μM
Compound: 3
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Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
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[PMID: 9322359] |
| Raji | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against human Raji cells after 3 days
Cytotoxicity against human Raji cells after 3 days
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[PMID: 10843573] |
| T-24 | IC50 |
21.09 μM
Compound: 7
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Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29921475] |
| Vero | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against african green monkey Vero cells after 3 days
Cytotoxicity against african green monkey Vero cells after 3 days
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[PMID: 10843573] |
| WISH | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against human Wish cells after 3 days
Cytotoxicity against human Wish cells after 3 days
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[PMID: 10843573] |
Chemical Information
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CAS No. 49620-13-5
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Appearance Solid
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Masse moléculaire 538.46
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Formule C30H18O10
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Color Light yellow to yellow
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SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=C13
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 10 mg/mL (18.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8571 mL | 9.2857 mL | 18.5715 mL | 46.4287 mL |
| 5 mM | 0.3714 mL | 1.8571 mL | 3.7143 mL | 9.2857 mL | |
| 10 mM | 0.1857 mL | 0.9286 mL | 1.8571 mL | 4.6429 mL | |
| 15 mM | 0.1238 mL | 0.6190 mL | 1.2381 mL | 3.0952 mL |
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