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Cat. No.: HY-168535

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SJ6145

SJ6145 is a potent ligand for KLHDC2^SBD, with the K_d of 16.9 μM in SPR test, IC₅₀ value of 42 μM in inhibiting KLHDC2^SBD binding to a di-Gly degron peptide test.

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CAS No.: 1010913-79-7
Formule: C₁₃H₁₁FN₂O₃S
Masse moléculaire:294.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SJ6145 Chemical Structure

CAS No.: 1010913-79-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

SJ6145 is a potent ligand for KLHDC2^SBD, with the K_d of 16.9 μM in SPR test, IC₅₀ value of 42 μM in inhibiting KLHDC2^SBD binding to a di-Gly degron peptide test^[1].

IC₅₀ & Target

KLHDC2

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase :

Chemical Information

CAS No. 1010913-79-7
Masse moléculaire 294.30
Formule C₁₃H₁₁FN₂O₃S
SMILES

O=C(CNC(CC1=CSC(C2=C(C=CC=C2)F)=N1)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SJ6145

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SJ6145 Related Classifications

HY-168535 Related Classifications