TAC 363
TAC 363 is a selective tachykinin NK-2 receptor antagonist. TAC 363 shows a rightward shift in the contractile response curve induced by Neurokinin A (HY-P0197) with a pA2 of 9.82. TAC 363 has a weak antagonistic effect on NK-1 receptors. TAC 363 can inhibit Neurokinin A-induced bronchoconstriction in guinea pigs with an ED50 of 0.3 mg/kg. TAC 363 can be used for the research of bronchial asthma.
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- CAS No.: 172081-08-2
- Formule: C38H48N8O6
- Masse moléculaire:712.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Tachykinin NK2 Receptor 9.82 (pA2) |
Chemical Information
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CAS No. 172081-08-2
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Masse moléculaire 712.84
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Formule C38H48N8O6
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SMILES
O=C(NCCOCC1=CC=CC=C1)N(CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(N)=O)NC(NC(C)(C)C)=O)=O)CC3=CNC4=CC=CC=C34)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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