TC-G 24
TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases.
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- CAS No.: 1257256-44-2
- Formule: C15H11ClN4O3
- Masse moléculaire:330.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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GSK-3β 17.1 nM (IC50) |
TC-G 24 (Compound 24) binds to the ATP binding site of GSK-3β[1].
TC-G 24 (1 µM, 4 h) blocks the FBW7α-mediated degradation of TPP1 in human embryonic kidney (HEK) 293T cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:293T cells
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Concentration:1 μM
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Incubation Time:4 h
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Result:Blocked the FBW7α-mediated degradation of TPP1
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old male C57BL/6N mice with weights averaging 22 g[1]
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Dosage:1, 5, and 15 mg/kg
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Administration:Intraperitoneal injection, once
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Result:Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).
Chemical Information
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CAS No. 1257256-44-2
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Masse moléculaire 330.73
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Formule C15H11ClN4O3
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SMILES
O=[N+](C1=CC=C(C2=NN=C(NC3=CC=C(C)C(Cl)=C3)O2)C=C1)[O-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Khanfar MA, et al. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J Med Chem. 2010 Dec 23;53(24):8534-45. [Content Brief]
[2]. Lihui Wang, et al. FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. Cell Metab. 2020 Nov 3;32(5):860-877.e9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TC-G 24 Related Classifications
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