Tenecteplase
Based on 1 Customer Validation
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke.
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- Pureté : 95.00%
- CAS No.: 191588-94-0
- Masse moléculaire:59.74 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Données de validation de MCE
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse ischemic thromboembolic models[3].
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Dosage:0.25-2.5 mg/kg
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Administration:iv, single dose
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Result:Reduced infarct volume.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 191588-94-0
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Appearance Liquid
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Masse moléculaire 59.74 kDa
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Color Colorless to light yellow
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SMILES
[Tenecteplase]
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Synonyms
TNK-tPA
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Livraison
Shipping with dry ice.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kvistad CE, et al. Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint, non-inferiority trial. Lancet Neurol. 2022 Jun;21(6):511-519. [Content Brief]
[2]. Thelengana A, et al. Tenecteplase versus alteplase in acute ischemic stroke: systematic review and meta-analysis[J]. Acta Neurologica Belgica, 2019, 119: 359-367. [Content Brief]
[3]. Correa-Paz C, et al., Pharmacological preclinical comparison of tenecteplase and alteplase for the treatment of acute stroke. J Cereb Blood Flow Metab. 2024 Aug;44(8):1306-1318. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tenecteplase Related Classifications
HY-108845 Related Classifications
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