TH1217
Based on 1 publication(s) in Google Scholar
TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.
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- Pureté: 97.04%
- CAS No.: 1862212-48-3
- Formule: C20H17BCl2N4O6
- Masse moléculaire:491.09
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TH1217
More
Activité biologique
IC50: 47 nM (dCTPase)[1]
TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%)[1].
TH1217 presents suitable mouse microsomal half-lives (109 minutes)[1].
TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1862212-48-3
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Appearance Solid
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Masse moléculaire 491.09
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Formule C20H17BCl2N4O6
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Color White to off-white
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SMILES
CC1=NC2=C(C(Cl)=C(Cl)C=C2N1CC3=CC=C(C=C3)[B-]45OC(C[N+]4(C)CC(O5)=O)=O)[N+]([O-])=O
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Synonyms
ZINC1775962367
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nucleic Acids Res
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. [Abstract]2021 Jan 8;49(D1):D1113-D1121. PMID: 33166390
Solvant et solubilité
DMSO : 125 mg/mL (254.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148. [Content Brief]
[2]. Gordon DE, et, al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22; 2020.03.22.002386. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0363 mL | 10.1814 mL | 20.3629 mL | 50.9072 mL |
| 5 mM | 0.4073 mL | 2.0363 mL | 4.0726 mL | 10.1814 mL | |
| 10 mM | 0.2036 mL | 1.0181 mL | 2.0363 mL | 5.0907 mL | |
| 15 mM | 0.1358 mL | 0.6788 mL | 1.3575 mL | 3.3938 mL | |
| 20 mM | 0.1018 mL | 0.5091 mL | 1.0181 mL | 2.5454 mL | |
| 25 mM | 0.0815 mL | 0.4073 mL | 0.8145 mL | 2.0363 mL | |
| 30 mM | 0.0679 mL | 0.3394 mL | 0.6788 mL | 1.6969 mL | |
| 40 mM | 0.0509 mL | 0.2545 mL | 0.5091 mL | 1.2727 mL | |
| 50 mM | 0.0407 mL | 0.2036 mL | 0.4073 mL | 1.0181 mL | |
| 60 mM | 0.0339 mL | 0.1697 mL | 0.3394 mL | 0.8485 mL | |
| 80 mM | 0.0255 mL | 0.1273 mL | 0.2545 mL | 0.6363 mL | |
| 100 mM | 0.0204 mL | 0.1018 mL | 0.2036 mL | 0.5091 mL |
TH1217 Related Classifications
HY-135909 Related Classifications
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