Way 100252
Way 100252 is a presynaptic GABA autoreceptor agonist. Way 100252 exerts its effect by inhibiting GABA release, and it suppresses GABA release induced by K+, Ca2+, Ouabain (HY-B1457) and electrical stimulation, with a more potent inhibitory effect on electrically evoked release. Way 100252 is used for studies related to GABAergic neurotransmission.
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- CAS No.: 129041-16-3
- Formule: C26H25NO2
- Masse moléculaire:383.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Way 100252 dose-dependently inhibits the release of [3H] GABA evoked by various stimuli in cross-cut rat cerebral cortical slices, with pD2 values of 5.8 (Ca2+), 7.4 (K+), 6.3 (electrical stimulation) and 6.0 (Ouabain (HY-B1457)) for different stimuli, respectively, and the maximum inhibitory effect ranges from 40% to 90%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 129041-16-3
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Masse moléculaire 383.48
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Formule C26H25NO2
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SMILES
O=C(CCCN(CC1=C2C=CC=CC2=CC=C1)CC3=C4C=CC=CC4=CC=C3)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Way 100252 Related Classifications
HY-116484 Related Classifications
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