YC-001
Based on 1 Customer Validation
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration.
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- Pureté: 99.43%
- CAS No.: 748778-73-6
- Formule: C12H7ClO2S2
- Masse moléculaire:282.77
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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rod opsin |
YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150–310%[1].
YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant[1].
YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC50 OF 0.98 µM[1].
YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH3T3 cells
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Concentration:0.5, 1, 5, 10, 20, 40 µM
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Incubation Time:
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Result:Improved the glycosylation profile of P23H opsin.
YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods[1].
YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old Abca4 −/−Rdh8−/− mice[1]
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Dosage:50, 200mg/kg
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Administration:I.P.
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Result:Protected Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration.
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Animal Model:C57BL/6 mouse[1]
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Dosage:200 mg/kg
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Administration:I.P.
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Result:Entered mouse eyes after systemic administration but is not retained for prolonged periods.
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Animal Model:C57BL/6 mice[1]
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Dosage:100 mg/kg, 200 mg/kg
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Administration:I.p.; daily, 24 days
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Result:Showed no acute toxicity.
Chemical Information
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CAS No. 748778-73-6
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Appearance Solid
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Masse moléculaire 282.77
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Formule C12H7ClO2S2
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Color White to yellow
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SMILES
O=C1OCC(C2=CC=C(Cl)S2)=C1C3=CC=CS3
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (353.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.5364 mL | 17.6822 mL | 35.3644 mL | 88.4111 mL |
| 5 mM | 0.7073 mL | 3.5364 mL | 7.0729 mL | 17.6822 mL | |
| 10 mM | 0.3536 mL | 1.7682 mL | 3.5364 mL | 8.8411 mL | |
| 15 mM | 0.2358 mL | 1.1788 mL | 2.3576 mL | 5.8941 mL | |
| 20 mM | 0.1768 mL | 0.8841 mL | 1.7682 mL | 4.4206 mL | |
| 25 mM | 0.1415 mL | 0.7073 mL | 1.4146 mL | 3.5364 mL | |
| 30 mM | 0.1179 mL | 0.5894 mL | 1.1788 mL | 2.9470 mL | |
| 40 mM | 0.0884 mL | 0.4421 mL | 0.8841 mL | 2.2103 mL | |
| 50 mM | 0.0707 mL | 0.3536 mL | 0.7073 mL | 1.7682 mL | |
| 60 mM | 0.0589 mL | 0.2947 mL | 0.5894 mL | 1.4735 mL | |
| 80 mM | 0.0442 mL | 0.2210 mL | 0.4421 mL | 1.1051 mL | |
| 100 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.8841 mL |
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