Z-Pro-prolinal
Based on 1 Customer Validation
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.9%
- CAS No.: 88795-32-8
- Formule: C18H22N2O4
- Masse moléculaire:330.38
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.4 nM (porcine PREP)[2]
Ki: 3.7 nM (PREP from bovine brain)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[3]
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Dosage:100 mg/kg
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Administration:Oral administration, once
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Result:Significantly increased the septal arginine-vasopressin (AVP) content.
Chemical Information
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CAS No. 88795-32-8
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Appearance Solid
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Masse moléculaire 330.38
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Formule C18H22N2O4
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Color White to off-white
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SMILES
O=C[C@H]1N(C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)CCC1
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Synonyms
N-Benzyloxycarbonyl-L-prolyl-L-prolinal
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tsuru D, et al. Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase. J Biochem. 1988;104(4):580-586. [Content Brief]
[2]. Kilpeläinen TP, et al. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomed Pharmacother. 2020;128:110253. [Content Brief]
[3]. Miura N, et al. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci Lett. 1995;196(1-2):128-130. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z-Pro-prolinal Related Classifications
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