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Cat. No.: HY-175239

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CAII/CAXII-IN-1

CAII/CAXII-IN-1 (compound 8d) is a CAII/CAXII inhibitor with IC₅₀ values of 0.38 µM and 0.61 µM for CAII and CAXII, respectively.

For research use only. We do not sell to patients.

Formula: C₂₅H₁₈BrN₃O₅S₂
Molecular Weight:584.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CAII/CAXII-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CAII/CAXII-IN-1 (compound 8d) is a CAII/CAXII inhibitor with IC₅₀ values of 0.38 µM and 0.61 µM for CAII and CAXII, respectively^[1].

All Carbonic Anhydrase Isoforms :

Chemical Information

Molecular Weight 584.46
Formula C₂₅H₁₈BrN₃O₅S₂
SMILES

CS(=O)(NC1=CC=C(NC2=NC(C(C3=O)=CC4=C(O3)C=CC(Br)=C4)=CS2)C=C1OC5=CC=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmed A, et al. Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches. Sci Rep. 2025 Jul 1;15(1):22032. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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