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Cat. No.: HY-184559

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CAII-IN-16

CAII-IN-16 is a selective inhibitor of carbonic anhydrase II (CA II), with an IC₅₀ of 0.5 nM against hCA II. CAII-IN-16 exhibits excellent intraocular pressure-lowering activity in a rabbit glaucoma animal model. CAII-IN-16 can be used for the research of glaucoma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2673323-38-9
Formule: C₂₅H₂₄FN₅O₁₀S
Masse moléculaire:605.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAII-IN-16 Chemical Structure

CAS No.: 2673323-38-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

hCA II

0.5 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Carbonic Anhydrase :

In Vitro

CAII-IN-16 (compound 19) exhibits an IC₅₀ value of 0.5 nM against hCA II. Its IC₅₀ values against hCA I, hCA IV, hCA IX and hCA XII are 0.59 μM, 0.003 μM, 0.012 μM and 0.010 μM, respectively. The selectivity ratios of hCA I/hCA II, hCA IX/hCA II, hCA IV/hCA II and hCA XII/hCA II are 1180, 42, 6.0 and 20.0, respectively, indicating its excellent isozyme selectivity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CAII-IN-16 (compound 19) (1% topical ophthalmic solution; single administration) achieves a maximum intraocular pressure reduction of 6.2 mmHg within 0.5 h in a rabbit model of acute ocular hypertension^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

How to Choose the Right Model Animal

Chemical Information

CAS No. 2673323-38-9
Masse moléculaire 605.55
Formule C₂₅H₂₄FN₅O₁₀S
SMILES

CC1=C(C(OC2=C1C=CC(OCC3=CN(N=N3)[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(NC5=CC=C(S(=O)(N)=O)C=C5)=O)O4)=C2)=O)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang Y, et al. Discovery of Subnanomolar and Highly Selective Carbonic Anhydrase II Inhibitors Featuring L-Shaped Scaffolds via Active-Site-Matched Fragment Growing. Journal of medicinal chemistry. 2026 Jun 25;69(12):14461-14491. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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