CAII-IN-16
CAII-IN-16 is a selective inhibitor of carbonic anhydrase II (CA II), with an IC50 of 0.5 nM against hCA II. CAII-IN-16 exhibits excellent intraocular pressure-lowering activity in a rabbit glaucoma animal model. CAII-IN-16 can be used for the research of glaucoma.
For research use only. We do not sell to patients.
- CAS No.: 2673323-38-9
- Formula: C25H24FN5O10S
- Molecular Weight:605.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA II 0.5 nM (IC50) |
CAII-IN-16 (compound 19) exhibits an IC50 value of 0.5 nM against hCA II. Its IC50 values against hCA I, hCA IV, hCA IX and hCA XII are 0.59 μM, 0.003 μM, 0.012 μM and 0.010 μM, respectively. The selectivity ratios of hCA I/hCA II, hCA IX/hCA II, hCA IV/hCA II and hCA XII/hCA II are 1180, 42, 6.0 and 20.0, respectively, indicating its excellent isozyme selectivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2673323-38-9
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Molecular Weight 605.55
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Formula C25H24FN5O10S
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SMILES
CC1=C(C(OC2=C1C=CC(OCC3=CN(N=N3)[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(NC5=CC=C(S(=O)(N)=O)C=C5)=O)O4)=C2)=O)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAII-IN-16 Related Classifications
HY-184559 Related Classifications
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