Canagliflozin-d₄  (Synonyms: JNJ 28431754-d₄)

Canagliflozin-d₄ (JNJ 28431754-d₄) is a deuterium labeled Canagliflozin. Canagliflozin is a selective SGLT2 inhibitor^[1].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

448.54

C₂₄H₂₁D₄FO₅S

1997338-61-0

842133-18-0

Solid

Light yellow to light brown

FC1=C([2H])C([2H])=C(C2=CC=C(CC3=C(C=CC([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3)C)S2)C([2H])=C1[2H]

Room temperature in continental US; may vary elsewhere.

• [1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555.  [Content Brief]