2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Carbonic anhydrase activator 1

Carbonic anhydrase activator 1 (Compound 17) is an orally active and a BBB-penetrable Carbonic anhydrase (CA) activator with KAs of 7.8, 3.9  and 2.1 μM for hCA I, hCA VA and hCA VII. Carbonic anhydrase activator 1 can be used for cancers, glaucoma, cardiovascular diseases and neurodegenerative disorders like epilepsy research.

For research use only. We do not sell to patients.

Carbonic anhydrase activator 1

Carbonic anhydrase activator 1 Chemical Structure

CAS No. : 2374923-30-3

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Carbonic anhydrase activator 1 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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Description

Carbonic anhydrase activator 1 (Compound 17) is an orally active and a BBB-penetrable Carbonic anhydrase (CA) activator with KAs of 7.8, 3.9  and 2.1 μM for hCA I, hCA VA and hCA VII. Carbonic anhydrase activator 1 can be used for cancers, glaucoma, cardiovascular diseases and neurodegenerative disorders like epilepsy research[1].

IC50 & Target[1]

hCA I

7.8 μM (KA)

hCA II

>150 μM (KA)

hCA VII

2.1 μM (KA)

hCA VA

3.9 μM (KA)

Cellular Effect
Cell Line Type Value Description References
CHO EC50
> 1000 nM
Compound: 15
Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay
Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay
[PMID: 31306001]
Molecular Weight

333.37

Formula

C17H11N5OS
CAS No.
SMILES

N#CC1=C(C2=CC=CO2)C(C#N)=C(N)N=C1SCC3=CC=NC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Carbonic anhydrase activator 1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase activator 12374923-30-3Carbonic anhydrase activator1Carbonic anhydrase activator-1Carbonic AnhydraseCarbonate dehydrataseActivatorCarbonic anhydraseCACancersGlaucomaCardiovascular diseasesNeurodegenerative disordersEpilepsyInhibitorinhibitorinhibit

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