1020719-11-2
1020719-11-2
Chemical Structure
(R,S)-Anatabine-d4
- CAS No.: 1020719-11-2
- Formula:C10H8D4N2
- Molecular Weight:164.24
IUPAC Name: 1,2,3,6-tetrahydro-2,3'-bipyridine-2',4',5',6'-d4
InChIKey: SOPPBXUYQGUQHE-AJEVBKBKSA-N
SMILES: [2H]C1=C(C2CC=CCN2)C([2H])=C([2H])C([2H])=N1
Biological Activity: (R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(R,S)-Anatabine-d4 | (R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use. | |||||||||||||||||||||
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(R,S)-Anatabine (Standard) | 97.98% | (R,S)-Anatabine (Standard) is the analytical standard of (R,S)-Anatabine (HY-126047A). This product is intended for research and analytical applications. (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use. | ||||||||||||||||||||
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(R,S)-Anatabine-d4 hydrochloride | (R,S)-Anatabine-d4 hydrochloride is the deuterium labeled (R,S)-Anatabine hydrochloride (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the?Solanaceae?family of?plants?that can be used as a specific marker for the detection of tobacco use. | |||||||||||||||||||||
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(Rac)-Nicotine EP impurity A-d4 (hydrochloride) | (Rac)-Nicotine EP impurity A-d4 (hydrochloride) is the deuterium labeled (Rac)-Nicotine EP impurity A hydrochloride. | |||||||||||||||||||||
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(R,S)-Anatabine | 99.67% | (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use. | ||||||||||||||||||||
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(S)-(-)-Anatabine | (S)-(-)-Anatabine is an NFκB/BACE-1 inhibitor with blood-brain barrier penetration. (S)-(-)-Anatabine inhibits NFκB activation via phosphorylation of its p65 subunit. (S)-(-)-Anatabine inhibits BACE-1 transcription and reduces BACE-1 protein levels. (S)-(-)-Anatabine lowers production of Aβ1-40 and Aβ1-42 by reducing β-cleavage of amyloid precursor protein without affecting α-cleavage. (S)-(-)-Anatabine can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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(R)-(+)-Anatabine | (R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent α4β2 nAChR agonist. Anatabine inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment. | |||||||||||||||||||||
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N-Nitrosoanatabine | 99.70% | N-Nitrosoanatabine (N-NAT; N'-Nitrosoanatabine) is a tobacco-specific nitrosamine that exists in tobacco, tobacco products and e-cigarettes. | ||||||||||||||||||||
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Anabasine (Standard) | ≥98% | Anabasine (Standard) is the analytical standard of Anabasine. This product is intended for research and analytical applications. Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 μM). | ||||||||||||||||||||
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(±)-Nornicotine (Standard) | ≥98% | (±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine (HY-W002112). This product is intended for research and analytical applications. (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia. | ||||||||||||||||||||
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Anabasine hydrochloride | Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM). | |||||||||||||||||||||
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(S)-Nornicotine | 98.59% | (S)-Nornicotine is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine is useful for research on tobacco dependence and pain. | ||||||||||||||||||||
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(±) Anabasine (Standard) | 98.15% | (±) Anabasine (Standard) is the analytical standard of (±) Anabasine (HY-W052144). This product is intended for research and analytical applications. (±) Anabasine is the racemic form of Anabasine (HY-B1532). (±) Anabasine stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities. | ||||||||||||||||||||
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(±) Anabasine hydrochloride | (±) Anabasine hydrochloride is the racemic form of Anabasine (HY-B1532). (±) Anabasine hydrochloride stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine hydrochloride inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine hydrochloride is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities. | |||||||||||||||||||||
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(S)-N-Nitrosoanatabine | (S) -N-Nitrosoanatabine ( (S) -N-NAT) is a potent carcinogen and biomarker of exposure to cigarette smoke. It′s found in a variety of tobacco products and oral snuff. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Lai FY, et al. Levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in raw wastewater as an innovative perspective for investigating population-wide exposure to third-hand smoke. Sci Rep. 2018 Sep 5;8(1):13254. [Content Brief]
