103141-09-9
103141-09-9
Chemical Structure
FPL 62064
- No. CAS: 103141-09-9
- Formula:C16H15N3O
- Molecular Weight:265.31
IUPAC Name: N-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
InChIKey: WKLGNFJHVJIZPK-UHFFFAOYSA-N
SMILES: COC1=CC=C(NC2=NN(C3=CC=CC=C3)C=C2)C=C1
Biological Activity: FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
FPL 62064 | 99.25% | FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.63
HY-W5437454-Methoxy-N-(4-(methylthio)phenyl)aniline -
Similarity Score 0.62
HY-146051Antitubercular agent-18 -
Similarity Score 0.62
HY-W011787DPPD -
Similarity Score 0.62
HY-W1426314-(Phenylazo)diphenylamine -
Similarity Score 0.61
HY-W543675N-Phenyl-N'-(2-methylphenyl)-p-phenylenediamine -
Similarity Score 0.61
HY-W170126CB6513745 -
Similarity Score 0.61
HY-103566ALY456236 free base -
Similarity Score 0.61
HY-W075531N1,N3-Di(pyridin-2-yl)benzene-1,3-diamine -
Similarity Score 0.60
HY-W543676N,N'-Di-o-tolyl-p-phenylenediamine -
Explore the MedChemAI to find more analogs
References
- [1]. Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. [Content Brief]
- [2]. Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. [Content Brief]
