103141-09-9
103141-09-9
Chemical Structure
FPL 62064
- CAS No.: 103141-09-9
- Formula:C16H15N3O
- Molecular Weight:265.31
IUPAC Name: N-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
InChIKey: WKLGNFJHVJIZPK-UHFFFAOYSA-N
SMILES: COC1=CC=C(NC2=NN(C3=CC=CC=C3)C=C2)C=C1
Biological Activity: FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FPL 62064 | 99.25% | FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity. | ||||||||||||||||||||
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References
- [1]. Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. [Content Brief]
- [2]. Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. [Content Brief]
Keywords
