112953-11-4
Chemical Structure
7-Hydroxystaurosporine
Synonym(s): UCN-01; KRX-0601
- CAS No.: 112953-11-4
- Formula:C28H26N4O4
- Molecular Weight:482.53
IUPAC Name: (5S,6R,7R,9R,16R)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one
InChIKey: PBCZSGKMGDDXIJ-HQCWYSJUSA-N
SMILES: C[C@]12N3C4=C(C5=CC=CC=C53)C([C@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78
Biological Activity: 7-Hydroxystaurosporine (UCN-01), a derivative of Staurosporine (HY-15141), is a selective protein kinase C (PKC) inhibitor with antitumor activity. 7-hydroxystaurosporine induces apoptosis and inhibits cell proliferation in colon carcinoma and leukemia cells, suppresses invasion and migration in glioblastoma cells. 7-Hydroxystaurosporine exhibits efficacy in breast cancer xenograft mouse models. 7-Hydroxystaurosporine can be used for colon carcinoma, breast cancer, glioblastoma and leukemia research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Hydroxystaurosporine | 97.8% | 7-Hydroxystaurosporine (UCN-01), a derivative of Staurosporine (HY-15141), is a selective protein kinase C (PKC) inhibitor with antitumor activity. 7-hydroxystaurosporine induces apoptosis and inhibits cell proliferation in colon carcinoma and leukemia cells, suppresses invasion and migration in glioblastoma cells. 7-Hydroxystaurosporine exhibits efficacy in breast cancer xenograft mouse models. 7-Hydroxystaurosporine can be used for colon carcinoma, breast cancer, glioblastoma and leukemia research. | ||||||||||||||||||||
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Similarity Score 1.00
HY-108262UCN-02 -
Similarity Score 0.86
HY-15141GStaurosporine (GMP) -
Similarity Score 0.85
HY-1205157-Oxostaurosporine -
Similarity Score 0.79
HY-1082633-Hydroxy Midostaurin -
Similarity Score 0.79
HY-108263A(S)-3-Hydroxy Midostaurin -
Similarity Score 0.79
HY-108263B(R)-3-Hydroxy Midostaurin -
Similarity Score 0.78
HY-171699Antibacterial agent 339 -
Similarity Score 0.75
HY-N124663′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine -
Similarity Score 0.73
HY-164041Staurosporine-Boc -
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References
- [1]. Shao RG, et al 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. Exp Cell Res. 1997 Aug 1;234(2):388-97. [Content Brief]
- [2]. Meng QH, et al. Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration. Acta Pharmacol Sin. 2005 Apr;26(4):492-9. [Content Brief]
- [3]. Koh J, et al. UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction. Breast Cancer. 2002;9(1):50-4. [Content Brief]
