115-63-9
115-63-9
Chemical Structure
Hexocyclium methylsulfate
- CAS No.: 115-63-9
- Formula:C21H36N2O5S
- Molecular Weight:428.59
InChIKey: NSILVESQCSUIAJ-UHFFFAOYSA-M
SMILES: O=S([O-])(OC)=O.OC(CN1CC[N+](C)(CC1)C)(C2CCCCC2)C3=CC=CC=C3
Biological Activity: Hexocyclium methylsulfate is a potent mAChR antagonist with pKi values of 8.9, 7.7, 8.4, 8.8 for M1, M2, M3, and M4 subtype, respectively. Hexocyclium methylsulfate has the potential for the research of duodenal ulcer and irritable bowel syndrome[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hexocyclium methylsulfate | 99.93% | Hexocyclium methylsulfate is a potent mAChR antagonist with pKi values of 8.9, 7.7, 8.4, 8.8 for M1, M2, M3, and M4 subtype, respectively. Hexocyclium methylsulfate has the potential for the research of duodenal ulcer and irritable bowel syndrome. | ||||||||||||||||||||
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References
- [1]. KASICH AM, et al. Hexocyclium methosulfate in active duodenal ulcer; evaluation of a new anticholinergic drug in conventional and long-acting forms, especially its effect on gastric pH as studied in 48-hour analysis. Am J Dig Dis. 1958 Jan;3(1):12-23. [Content Brief]
- [2]. Waelbroeck M, et al. Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes. Br J Pharmacol. 1994 Jun;112(2):505-14.
Keywords
