115388-96-0
Chemical Structure
H-D-Phe-Pip-Arg-pNA acetate
Synonym(s): S-2238 acetate
- CAS No.: 115388-96-0
- Formula:C29H40N8O7
- Molecular Weight:612.68
IUPAC Name: (S)-1-(D-phenylalanyl)-N-((S)-5-guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)piperidine-2-carboxamide acetate
InChIKey: YVHLNJUMPNYROS-FMVQVTEISA-N
SMILES: O=C([C@H](N)CC1=CC=CC=C1)N2[C@H](C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCC2.CC(O)=O
Biological Activity: H-D-Phe-Pip-Arg-pNA acetate (S-2238 acetate) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA acetate is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA acetate can be used in biochemical detection-related studies[1][2].
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H-D-Phe-Pip-Arg-pNA acetate | 99.81% | H-D-Phe-Pip-Arg-pNA acetate (S-2238 acetate) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA acetate is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA acetate can be used in biochemical detection-related studies. | ||||||||||||||||||||
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Similarity Score 0.96
HY-123275H-D-Phe-Pip-Arg-pNA -
Similarity Score 0.95
HY-123275AH-D-Phe-Pip-Arg-pNA hydrochloride -
Similarity Score 0.95
HY-123275CH-D-Phe-Pip-Arg-pNA dihydrochloride -
Similarity Score 0.78
HY-P0021D-Lys(Z)-Pro-Arg-pNA -
Similarity Score 0.76
HY-P4470Phe-Pro-Ala-pNA -
Similarity Score 0.76
HY-P0021AD-Lys(Z)-Pro-Arg-pNA diacetate -
Similarity Score 0.76
HY-138109D-Pro-Phe-Arg-pNA hydrochloride -
Similarity Score 0.72
HY-126809Bz-Pro-Phe-Arg-pNA -
Similarity Score 0.72
HY-126809ABz-Pro-Phe-Arg-pNA hydrochloride -
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References
- [1]. Larsen M L, et al. Assay of plasma heparin using thrombin and the chromogenic substrate H-D-Phe-Pip-Arg-pNA (S-2238). Thrombosis Research, 1978, 13(2): 285-288.
- [2]. Nakajima N, et al. Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus. Bioscience, biotechnology, and biochemistry. 1993 Oct;57(10):1726-30. [Content Brief]
