116-38-1
116-38-1
Chemical Structure
Edrophonium chloride
- CAS No.: 116-38-1
- Formula:C10H16ClNO
- Molecular Weight:201.69
IUPAC Name: N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium chloride
InChIKey: BXKDSDJJOVIHMX-UHFFFAOYSA-N
SMILES: C[N+](C)(CC)C1=CC=CC(O)=C1.[Cl-]
Biological Activity: Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis[1][2][3].
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Edrophonium chloride | 98.68% | Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis. | ||||||||||||||||||||
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Edrophonium chloride (Standard) | ≥98% | Edrophonium chloride (Standard) is the analytical standard of Edrophonium chloride (HY-B0882). This product is intended for research and analytical applications. Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis. | ||||||||||||||||||||
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Edrophonium-d5 chloride | Edrophonium-d5 chloride is the deuterium labeled Edrophonium chloride (HY-B0882). Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis. | |||||||||||||||||||||
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References
- [1]. Pitt B, et al. Use of edrophonium chloride (tensilon) to detect early digitalis toxicity. Am J Cardiol. 1966 Oct;18(4):557-65. [Content Brief]
- [2]. Boyle NA, et al. Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. J Med Chem. 1997 Sep 12;40(19):3009-13. [Content Brief]
- [3]. Yost CS, et al. Clinical concentrations of edrophonium enhance desensitization of the nicotinic acetylcholine receptor. Anesth Analg. 1994 Mar;78(3):520-6. [Content Brief]
