1161826-19-2
Chemical Structure
KL-50
- CAS No.: 1161826-19-2
- Formula:C7H7FN6O2
- Molecular Weight:226.17
InChIKey: RXJOSBAVDXNQEY-UHFFFAOYSA-N
SMILES: O=C(C(N=CN12)=C2N=NN(CCF)C1=O)N
Biological Activity: KL-50 is an orally active N3-(2-fluoroethyl) imidazotetrazine DNA alkylating agent with selectivity for MGMT-deficient cells. KL-50 introduces a 2-fluoroethyl group at the O6 position of guanine, forming O6-(2-fluoroethyl) guanine (O6FEtG) lesions and further generating DNA interstrand crosslinks (ICLs). KL-50 induces DNA double-strand breaks, activates ATR-CHK1 and ATM-CHK2 DNA damage responses, and causes cell cycle arrest and micronucleus formation. KL-50 can be used for glioblastoma and DNA damage response research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KL-50 | 99.82% | KL-50 is an orally active N3-(2-fluoroethyl) imidazotetrazine DNA alkylating agent with selectivity for MGMT-deficient cells. KL-50 introduces a 2-fluoroethyl group at the O6 position of guanine, forming O6-(2-fluoroethyl) guanine (O6FEtG) lesions and further generating DNA interstrand crosslinks (ICLs). KL-50 induces DNA double-strand breaks, activates ATR-CHK1 and ATM-CHK2 DNA damage responses, and causes cell cycle arrest and micronucleus formation. KL-50 can be used for glioblastoma and DNA damage response research. | ||||||||||||||||||||
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References
- [1]. Lin K, et al. Compounds and methods for treating cancers that are MGMT deficient regardless of MMR status. WO 2023/049806 A1. 2023-03-30.
- [2]. McCord M, et al. The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma. Neuro-oncology. 2025 Mar 07;27(3):644-651.
- [3]. Huseman ED, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal of the American Chemical Society. 2024 Jul 10;146(27):18241-18252. [Content Brief]
