116355-81-8
Chemical Structure
cCF10
- CAS No.: 116355-81-8
- Formula:C40H67N7O9
- Molecular Weight:790.00
InChIKey: YTHCSYRAOWULDD-RDGLCLRFSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Biological Activity: cCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p)ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria[1][2][3].
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cCF10 | cCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p)ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria. | |||||||||||||||||||||
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- [1]. Buttaro BA, et al. Cell-associated pheromone peptide (cCF10) production and pheromone inhibition in Enterococcus faecalis. J Bacteriol. 2000 Sep;182(17):4926-33. [Content Brief]
- [2]. Zhu L, et al. Pheromone cCF10 inhibits the antibiotic persistence of Enterococcus faecalis by modulating energy metabolism. Front Microbiol. 2024 Jul 8;15:1408701. [Content Brief]
- [3]. Mori M, et al. Structure of cCF10, a peptide sex pheromone which induces conjugative transfer of the Streptococcus faecalis tetracycline resistance plasmid, pCF10. J Biol Chem. 1988 Oct 5;263(28):14574-8. [Content Brief]
Keywords
