123-93-3
Chemical Structure
2,2'-Thiodiacetic acid
Synonym(s): Thiodiglycolic acid
- No. CAS: 123-93-3
- Formula:C4H6O4S
- Molecular Weight:150.15
IUPAC Name: 2,2'-thiodiacetic acid
InChIKey: UVZICZIVKIMRNE-UHFFFAOYSA-N
SMILES: O=C(O)CSCC(=O)O
Biological Activity: 2,2'-Thiodiacetic acid (Thiodiglycolic acid) is a metabolite of the anticancer agent Ifosfamide (HY-17419). 2,2'-Thiodiacetic acid is also a biomarker of vinyl chloride monomer exposure in urine. 2,2'-Thiodiacetic acid increases the DNA damage response markers γH2AX, pCHK1, and pATR. 2,2'-Thiodiacetic acid induces Mitochondrial dysfunction. 2,2'-Thiodiacetic acid can be used in research on non-alcoholic fatty liver disease[1][2][3][4][5].
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2,2'-Thiodiacetic acid | 99.90% | 2,2'-Thiodiacetic acid (Thiodiglycolic acid) is a metabolite of the anticancer agent Ifosfamide (HY-17419). 2,2'-Thiodiacetic acid is also a biomarker of vinyl chloride monomer exposure in urine. 2,2'-Thiodiacetic acid increases the DNA damage response markers γH2AX, pCHK1, and pATR. 2,2'-Thiodiacetic acid induces Mitochondrial dysfunction. 2,2'-Thiodiacetic acid can be used in research on non-alcoholic fatty liver disease. | ||||||||||||||||||||
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2,2'-Thiodiacetic acid-d4 | 2,2'-Thiodiacetic acid-d4 is the d4-labeled 2,2'-Thiodiacetic acid (HY-W012583). 2,2'-Thiodiacetic acid (Thiodiglycolic acid) is a metabolite of the anticancer agent Ifosfamide (HY-17419). 2,2'-Thiodiacetic acid is also a biomarker of vinyl chloride monomer exposure in urine. 2,2'-Thiodiacetic acid increases the DNA damage response markers γH2AX, pCHK1, and pATR. 2,2'-Thiodiacetic acid induces Mitochondrial dysfunction. 2,2'-Thiodiacetic acid can be used in research on non-alcoholic fatty liver disease. | |||||||||||||||||||||
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References
- [1]. Wang CW, et al. Urinary thiodiglycolic acid is associated with increased risk of non-alcoholic fatty liver disease in children living near a petrochemical complex. Environment international. 2019 Oct;131:104978. [Content Brief]
- [2]. Hakulinen H, et al. Detection of degradation products of chemical warfare agents in Halabja soil: In vitro genotoxicity and effects in exposed humans. Journal of hazardous materials. 2026 Oct 10;518:143882. [Content Brief]
- [3]. Haynes EN, et al. Urinary Metabolites of Volatile Organic Compounds in a Subset of East Palestine, Ohio Residents Five Months Following the Train Derailment Disaster. Environmental science & technology. 2026 Sep 29;60(38):26953-26960. [Content Brief]
- [4]. Kalkenari FA, et al. Evaluation of thiodiglycolic acid as a urinary biomarker for exposure to vinyl chloride monomer: Development and analytical validation of a colorimetric method based on metal-organic frameworks. Journal of occupational and environmental hygiene. 2026 Sep 15. [Content Brief]
- [5]. Visarius TM, et al. Thiodiglycolic acid is excreted by humans receiving ifosfamide and inhibits mitochondrial function in rats. Drug Metab Dispos. 1998 Mar;26(3):193-6. [Content Brief]
