125-33-7
125-33-7
Chemical Structure
Primidone
- CAS No.: 125-33-7
- Formula:C12H14N2O2
- Molecular Weight:218.25
IUPAC Name: 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione
InChIKey: DQMZLTXERSFNPB-UHFFFAOYSA-N
SMILES: O=C(C1(CC)C2=CC=CC=C2)NCNC1=O
Biological Activity: Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].
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Primidone | 99.96% | Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent. | ||||||||||||||||||||
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Primidone (Standard) | 99.97% | Primidone (Standard) is the analytical standard of Primidone. This product is intended for research and analytical applications. Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent. | ||||||||||||||||||||
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Primidone-d5 | 99.00% | Primidone-d5 is the deuterium labeled Primidone. Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.67
HY-124148Fenimide -
Similarity Score 0.65
HY-165469Methetoin -
Similarity Score 0.65
HY-126043(R)-Mephenytoin -
Similarity Score 0.65
HY-B1184AR(S)-Mephenytoin (Standard) -
Similarity Score 0.65
HY-B1184RMephenytoin (Standard) -
Similarity Score 0.64
HY-114692Eterobarb -
Similarity Score 0.63
HY-U00001Phenglutarimid -
Similarity Score 0.62
HY-U00001ARPhenglutarimid hydrochloride (Standard) -
Similarity Score 0.61
HY-N13432Cyclo(Ala-Phe) -
Explore the MedChemAI to find more analogs
References
- [1]. Krügel U, et al., Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 May;158(5):856-867. [Content Brief]
- [2]. Riebeling T, et al., Primidone blocks RIPK1-driven cell death and inflammation. Cell Death Differ. 2021 May;28(5):1610-1626. [Content Brief]
- [3]. Vogelnik Žakelj K, et al., Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor. Parkinsonism Relat Disord. 2024 Nov;128:107151. [Content Brief]
