1354825-58-3
1354825-58-3
Chemical Structure
WEHI-345
- CAS No.: 1354825-58-3
- Formula:C22H23N7O
- Molecular Weight:401.46
IUPAC Name: N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropyl)isonicotinamide
InChIKey: LEBSTCDZKUSVOY-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NCC(C)(N2N=C(C3=CC=C(C)C=C3)C4=C(N)N=CN=C42)C
Biological Activity: WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation[1].
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WEHI-345 | 99.29% | WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. | ||||||||||||||||||||
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