1426449-01-5
Chemical Structure
Labuxtinib
Synonym(s): EVT-8565072; THB335
- CAS No.: 1426449-01-5
- Formula:C20H16FN5O2
- Molecular Weight:377.37
InChIKey: RHNJOZCVGSBEAG-KBPBESRZSA-N
SMILES: CC1=CC=C(C2=NOC([C@@H]3[C@H](C3)F)=N2)C=C1NC(C4=CN=C5N4C=CC=C5)=O
Biological Activity: Labuxtinib (EVT-8565072; THB335) is a potent dual inhibitor of c-Kit and PDGFR. Labuxtinib exhibits potent inhibitory activity against wild-type c-Kit (IC50 = 0.005 μM). Labuxtinib inhibits SCF-dependent and PDGF-dependent cell proliferation, and blocks the proliferation of cells dependent on c-Kit or PDGFR signaling pathways. In animal models of skin allergy, Labuxtinib depletes skin mast cells and significantly alleviates anaphylactic shock responses. Labuxtinib can be used in research on mast cell-related diseases, respiratory diseases, inflammatory diseases, fibrotic diseases, metabolic diseases, and other related conditions[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Labuxtinib | 98.74% | Labuxtinib (EVT-8565072; THB335) is a potent dual inhibitor of c-Kit and PDGFR. Labuxtinib exhibits potent inhibitory activity against wild-type c-Kit (IC50 = 0.005 μM). Labuxtinib inhibits SCF-dependent and PDGF-dependent cell proliferation, and blocks the proliferation of cells dependent on c-Kit or PDGFR signaling pathways. In animal models of skin allergy, Labuxtinib depletes skin mast cells and significantly alleviates anaphylactic shock responses. Labuxtinib can be used in research on mast cell-related diseases, respiratory diseases, inflammatory diseases, fibrotic diseases, metabolic diseases, and other related conditions. | ||||||||||||||||||||
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Keywords
