1426802-50-7
1426802-50-7
Chemical Structure
GSK805
- CAS No.: 1426802-50-7
- Formula:C23H18Cl2F3NO4S
- Molecular Weight:532.36
IUPAC Name: N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
InChIKey: CEICQMBWAQAIQX-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(Cl)=C(C2=CC=CC=C2OC(F)(F)F)C(Cl)=C1)CC3=CC=C(S(=O)(CC)=O)C=C3
Biological Activity: GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity[1].
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GSK805 | 99.83% | GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity. | ||||||||||||||||||||
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