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  3. XY101

XY101 

Cat. No.: HY-128604 Purity: 98.88%
Handling Instructions

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM.

For research use only. We do not sell to patients.

XY101 Chemical Structure

XY101 Chemical Structure

CAS No. : 2349368-16-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 434 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM[1].

IC50 & Target

IC50: 30 nM (RORγ)[1]
Kd: 380 nM (RORγ)[1]

In Vitro

XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA)[1].

In Vivo

XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss[1].

Molecular Weight

563.48

Formula

C₂₅H₂₀F₇NO₄S

CAS No.

2349368-16-5

SMILES

O=S(C1=CC=C(CC(NC2=CC=C(C3=C(F)C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2)=O)C=C1)(CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (443.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7747 mL 8.8734 mL 17.7469 mL
5 mM 0.3549 mL 1.7747 mL 3.5494 mL
10 mM 0.1775 mL 0.8873 mL 1.7747 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

XY101XY 101XY-101RORRAR-related orphan receptorInhibitorinhibitorinhibit

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Product Name:
XY101
Cat. No.:
HY-128604
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