1. Metabolic Enzyme/Protease
  2. ROR
  3. XY101

XY101 

Cat. No.: HY-128604
Handling Instructions

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM.

For research use only. We do not sell to patients.

XY101 Chemical Structure

XY101 Chemical Structure

CAS No. : 2349368-16-5

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Description

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM[1].

IC50 & Target

IC50: 30 nM (RORγ)[1]
Kd: 380 nM (RORγ)[1]

In Vitro

XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA)[1].

In Vivo

XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss[1].

Molecular Weight

563.48

Formula

C₂₅H₂₀F₇NO₄S

CAS No.

2349368-16-5

SMILES

O=S(C1=CC=C(CC(NC2=CC=C(C3=C(F)C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2)=O)C=C1)(CC)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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XY101
Cat. No.:
HY-128604
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