1446090-79-4

Lifirafenib Chemical Structure
1446090-79-4

Chemical Structure

Lifirafenib

Synonym(s): BGB-283

  • CAS No.: 1446090-79-4
  • Formula:C25H17F3N4O3
  • Molecular Weight:478.42

IUPAC Name: 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

InChIKey: NGFFVZQXSRKHBM-FKBYEOEOSA-N

SMILES: O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1

Biological Activity: Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.

Cat. No. Nom du produit Pureté Description Pricing
HY-18957 		Lifirafenib 98.01% Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Keywords