1446090-79-4
1446090-79-4
Chemical Structure
Lifirafenib
Synonym(s): BGB-283
- CAS No.: 1446090-79-4
- Formula:C25H17F3N4O3
- Molecular Weight:478.42
IUPAC Name: 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
InChIKey: NGFFVZQXSRKHBM-FKBYEOEOSA-N
SMILES: O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1
Biological Activity: Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lifirafenib | 98.01% | Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. | ||||||||||||||||||||
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