149488-17-5
149488-17-5
Chemical Structure
Trovirdine
Synonym(s): LY300046
- CAS No.: 149488-17-5
- Formula:C13H13BrN4S
- Molecular Weight:337.24
IUPAC Name: 1-(5-bromopyridin-2-yl)-3-(2-(pyridin-2-yl)ethyl)thiourea
InChIKey: HOCFDYZWQYGULA-UHFFFAOYSA-N
SMILES: S=C(NCCC1=NC=CC=C1)NC2=NC=C(Br)C=C2
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Trovirdine | 98.62% | Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate. | ||||||||||||||||||||
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References
- Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127.
- Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
Keywords
