153-87-7
153-87-7
Chemical Structure
Oxypertine
Synonym(s): WIN-18501-2
- CAS. Nr.: 153-87-7
- Formula:C23H29N3O2
- Molecular Weight:379.50
IUPAC Name: 5,6-dimethoxy-2-methyl-3-(2-(4-phenylpiperazin-1-yl)ethyl)-1H-indole
InChIKey: XCWPUUGSGHNIDZ-UHFFFAOYSA-N
SMILES: CC(NC1=C2C=C(OC)C(OC)=C1)=C2CCN3CCN(CC3)C4=CC=CC=C4
Biological Activity: Oxypertine (WIN-18501-2) is a neuroprotective agent. Oxypertine shows high affinity for the 5-HT2 and dopamine D2 receptors with Kis of 8.6 nM and 30 nM, respectively. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Oxypertine | 99.84% | Oxypertine (WIN-18501-2) is a neuroprotective agent. Oxypertine shows high affinity for the 5-HT2 and dopamine D2 receptors with Kis of 8.6 nM and 30 nM, respectively. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia. | ||||||||||||||||||||
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Oxypertine (Standard) | ≥98% | Oxypertine (Standard) is the analytical standard of Oxypertine. This product is intended for research and analytical applications. Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia. | ||||||||||||||||||||
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Donitriptan hydrochloride | 99.86% | Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively. | ||||||||||||||||||||
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Donitriptan | 98.06% | Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively. | ||||||||||||||||||||
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Centhaquin (Standard) | ≥98% | Centhaquin (Standard) is the analytical standard of Centhaquin. This product is intended for research and analytical applications. Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models. | ||||||||||||||||||||
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Enpp-1-IN-6 | Enpp-1-IN-6 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-6 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51). | |||||||||||||||||||||
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Cutamesine | 99.18% | Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects. | ||||||||||||||||||||
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ROS inducer 1 | ROS inducer 1 (compound I29) is a fungicide, with EC50 against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) of 5.73, 6.62 and 9.05 μg/mL. ROS inducer 1 can effectively induce the production of ROS in Xanthomonas cells and inhibit rice bacterial blight. ROS inducer 1 has the potential to study bacterial infection in crops. | |||||||||||||||||||||
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hAChE/hBACE-1-IN-4 | hAChE/hBACE-1-IN-4 (compound AK-2) is a quinazoline derivative. hAChE/hBACE-1-IN-4 shows significant inhibitory activity against hAChE and hBACE-1 enzymes (hAChE, IC50=0.283 μM; hBACE-1, IC50=0.231 μM). hAChE/hBACE-1-IN-4 has the potential to inhibit Aβ aggregation. hAChE/hBACE-1-IN-4 has non-neurotoxicity , blood-brain barrier permeability and oral activity. hAChE/hBACE-1-IN-4 can be used in Alzheimer's disease research. | |||||||||||||||||||||
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EMD 56551 | EMD 56551 is a potent and selective 5-HT1A receptor agonist. EMD 56551 exerts anxiolytic activity. | |||||||||||||||||||||
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Alpertine | Alpertine is an antipsychotic agent extracted from patent US 5955459 A. | |||||||||||||||||||||
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Peraquinsin | 98.65% | Peraquinsin is a MK2 activator. Peraquinsin can be used for the research of vascular disorder or endothelial barrier disorder. Peraquinsin also is an antihypertensive agent. | ||||||||||||||||||||
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References
- [1]. H Miranda, et al. Effects of oxypertine on the isolated vas deferens of the rat. Br J Pharmacol. 1978 Apr;62(4):515-8. [Content Brief]
- [2]. T Moroji, et al. Neurochemical and behavioral studies on the mode of action of oxypertine. Arzneimittelforschung. 1986 May;36(5):804-8. [Content Brief]
- [3]. M Hong, et al. Comparison of the acute actions of amine-depleting drugs and dopamine receptor antagonists on dopamine function in the brain in rats. [Content Brief]
- [4]. Megens AA, et al. Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent? Prog Med Chem. 1996;33:185-232. [Content Brief]
