153808-85-6
Chemical Structure
Cadrofloxacin
Synonym(s): Caderofloxacin; CS-940
- CAS No.: 153808-85-6
- Formula:C19H20F3N3O4
- Molecular Weight:411.38
IUPAC Name: (S)-1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: QBDBUKJBJJWZMG-VIFPVBQESA-N
SMILES: O=C(O)C1=CN(C2=C(C1=O)C=C(C(N3C[C@@H](NCC3)C)=C2OC(F)F)F)C4CC4
Biological Activity: Cadrofloxacin (Caderofloxacin; CS-940) is an orally active antibacterial agent that exhibits significant bactericidal activity against quinolone-resistant Staphylococcus aureus, as well as various Gram-positive, Gram-negative, and anaerobic bacteria. Cadrofloxacin functions by inhibiting bacterial DNA topoisomerase IV and DNA gyrase, thereby blocking the process of bacterial DNA replication. Cadrofloxacin has been shown to be effective in treating systemic infections and experimental Klebsiella pneumoniae pneumonia in mice. Cadrofloxacin is widely used in research concerning systemic bacterial infections and bacterial pneumonia[1][2][3].
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Cadrofloxacin | 98.21% | Cadrofloxacin (Caderofloxacin; CS-940) is an orally active antibacterial agent that exhibits significant bactericidal activity against quinolone-resistant Staphylococcus aureus, as well as various Gram-positive, Gram-negative, and anaerobic bacteria. Cadrofloxacin functions by inhibiting bacterial DNA topoisomerase IV and DNA gyrase, thereby blocking the process of bacterial DNA replication. Cadrofloxacin has been shown to be effective in treating systemic infections and experimental Klebsiella pneumoniae pneumonia in mice. Cadrofloxacin is widely used in research concerning systemic bacterial infections and bacterial pneumonia. | ||||||||||||||||||||
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Similarity Score 0.99
HY-116228ACadrofloxacin hydrochloride -
Similarity Score 0.87
HY-10581RGatifloxacin (Standard) -
Similarity Score 0.87
HY-10581AGatifloxacin hydrochloride -
Similarity Score 0.83
HY-10581BGatifloxacin mesylate -
Similarity Score 0.80
HY-123175Chinfloxacin -
Similarity Score 0.76
HY-W0978673-Desmethyl Gatifloxacin -
Similarity Score 0.75
HY-B0159Balofloxacin -
Similarity Score 0.75
HY-B0159ABalofloxacin dihydrate -
Similarity Score 0.75
HY-132476SN-Methyl Gatifloxacin-d3 -
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References
- [1]. Masuda N, et al. In vitro and in vivo antibacterial activities of CS-940, a new 6-fluoro-8-difluoromethoxy quinolone[J]. Antimicrobial agents and chemotherapy, 1996, 40(5): 1201-1207.
- [2]. Ruiz J. Transferable Mechanisms of Quinolone Resistance from 1998 Onward. Clin Microbiol Rev. 2019 Aug 14;32(4):e00007-19.
- [3]. Bryskier A, et al. Fluoroquinolones and tuberculosis. Expert Opin Investig Drugs. 2002 Feb;11(2):233-58. [Content Brief]
