1591823-76-5
1591823-76-5
Chemical Structure
Ulonivirine
Synonym(s): MK-8507
- CAS No.: 1591823-76-5
- Formula:C18H8ClF6N5O3
- Molecular Weight:491.73
InChIKey: YSFHLBYWQCLYIY-UHFFFAOYSA-N
SMILES: N#CC1=CC(Cl)=CC(OC2=C(C(F)(F)F)N=CN(CC3=NNC(C(C(F)(F)F)=C3)=O)C2=O)=C1
Biological Activity: Ulonivirine is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor that binds to the classical non-nucleoside reverse transcriptase inhibitor hydrophobic binding pocket adjacent to the polymerase active site of HIV-1 reverse transcriptase. Ulonivirine can be used in studies related to HIV-1 infection[1][2][3].
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Ulonivirine | 98.61% | Ulonivirine is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor that binds to the classical non-nucleoside reverse transcriptase inhibitor hydrophobic binding pocket adjacent to the polymerase active site of HIV-1 reverse transcriptase. Ulonivirine can be used in studies related to HIV-1 infection. | ||||||||||||||||||||
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References
- [1]. Schürmann D, et al. Single Oral Doses of MK-8507, a Novel Non-Nucleoside Reverse Transcriptase Inhibitor, Suppress HIV-1 RNA for a Week. J Acquir Immune Defic Syndr. 2022;89(2):191-198. [Content Brief]
- [2]. Gillespie G, et al. Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK-8507, an Investigational, Oral, Once-Weekly Nonnucleoside Reverse Transcriptase Inhibitor. J Clin Pharmacol. 2022;62(2):199-205. [Content Brief]
- [3]. Ankrom W, et al. Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV. Antimicrob Agents Chemother. 2021;65(12):e0093521. [Content Brief]
Keywords
