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Cat. No.: HY-14361

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MK-4965

MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 920035-77-4
Formula: C₂₀H₁₃Cl₂N₅O₂
Molecular Weight:426.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MK-4965 Chemical Structure

CAS No.: 920035-77-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)^[1]

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
MT4	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
SUP-T1	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]

Chemical Information

CAS No. 920035-77-4
Molecular Weight 426.26
Formula C₂₀H₁₃Cl₂N₅O₂
SMILES

N#CC1=CC(Cl)=CC(OC2=CC(OCC3=NNC4=NC(N)=CC=C43)=CC=C2Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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MK-4965

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MK-4965 Related Classifications

HY-14361 Related Classifications