1637532-68-3
Chemical Structure
STAT6-IN-1
- CAS No.: 1637532-68-3
- Formula:C33H37IN3O7P
- Molecular Weight:745.54
IUPAC Name: 4-((E)-4-(((S)-1-((S)-2-((4-iodophenyl)(phenyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobut-2-en-2-yl)phenyl dihydrogen phosphate
InChIKey: CGLGRSOJPUXNFA-YVXBOAIISA-N
SMILES: O=C([C@H]1N(CCC1)C([C@H](C(C)(C)C)NC(/C=C(C2=CC=C(C=C2)OP(O)(O)=O)\C)=O)=O)N(C3=CC=CC=C3)C4=CC=C(C=C4)I
Biological Activity: STAT6-IN-1 (Compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1][2][3].
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STAT6-IN-1 | 99.81% | STAT6-IN-1 (Compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer. | ||||||||||||||||||||
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References
- [1]. Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84. [Content Brief]
- [2]. John S, et al. Stat6 inhibitors. Patent WO2014182928A2.
- [3]. Zhang F, et al. Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment. Bioact Mater. 2023 Aug 14;31:231-246. [Content Brief]
