17833-53-3
Chemical Structure
N-Methyl-DL-aspartic acid
- CAS No.: 17833-53-3
- Formula:C5H9NO4
- Molecular Weight:147.13
IUPAC Name: methylaspartic acid
InChIKey: HOKKHZGPKSLGJE-UHFFFAOYSA-N
SMILES: O=C(O)CC(C(O)=O)NC
Biological Activity: N-Methyl-DL-aspartic acid acts as an agonist for N-methyl-D-aspartic acid receptors and D-isomer-specific aspartate receptors. N-Methyl-DL-aspartic acid activates hypothalamic neurons that regulate gonadotropin-releasing hormone secretion, and stimulates prepubertal male rhesus monkeys to produce sustained intermittent gonadotropin-releasing hormone secretion and pulsatile luteinizing hormone secretion. N-Methyl-DL-aspartic acid activates excitatory effects mediated by N-methyl-D-aspartic acid receptors. N-Methyl-DL-aspartic acid exhibits convulsant effects, inducing clonic convulsions with loss of righting reflex, generalized tonic-clonic seizures or persistent clonic seizures. N-Methyl-DL-aspartic acid causes precocious puberty. N-Methyl-DL-aspartic acid can be used in studies related to convulsions and seizures[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Methyl-DL-aspartic acid | 99.02% | N-Methyl-DL-aspartic acid acts as an agonist for N-methyl-D-aspartic acid receptors and D-isomer-specific aspartate receptors. N-Methyl-DL-aspartic acid activates hypothalamic neurons that regulate gonadotropin-releasing hormone secretion, and stimulates prepubertal male rhesus monkeys to produce sustained intermittent gonadotropin-releasing hormone secretion and pulsatile luteinizing hormone secretion. N-Methyl-DL-aspartic acid activates excitatory effects mediated by N-methyl-D-aspartic acid receptors. N-Methyl-DL-aspartic acid exhibits convulsant effects, inducing clonic convulsions with loss of righting reflex, generalized tonic-clonic seizures or persistent clonic seizures. N-Methyl-DL-aspartic acid causes precocious puberty. N-Methyl-DL-aspartic acid can be used in studies related to convulsions and seizures. | ||||||||||||||||||||
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N-Methyl-DL-aspartic acid (Standard) | ≥98% | N-Methyl-DL-aspartic acid is a glutamate analogue and a NMDA receptor agonist and can be used for neurological diseases research. | ||||||||||||||||||||
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References
- [1]. Czuczwar SJ, et al. Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents. European journal of pharmacology. 1985 Feb 05;108(3):273-80. [Content Brief]
- [2]. Lauretti GR, et al. The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole. Neuropharmacology. 1994 Feb;33(2):155-60. [Content Brief]
- [3]. Gay VL, et al. Sustained intermittent release of gonadotropin-releasing hormone in the prepubertal male rhesus monkey induced by N-methyl-DL-aspartic acid. Neuroendocrinology. 1988 Aug;48(2):147-52. [Content Brief]
