1809031-84-2
Chemical Structure
P62-mediated mitophagy inducer
- CAS No.: 1809031-84-2
- Formula:C14H9IN4O2
- Molecular Weight:392.15
IUPAC Name: 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole
InChIKey: LSVWEYNSNZJEGB-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC(C2=CN(C3=CC=CC(I)=C3)N=N2)=CC=C1)[O-]
Biological Activity: P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1].
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P62-mediated mitophagy inducer | 99.54% | P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential. | ||||||||||||||||||||
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