183718-70-9
183718-70-9
Chemical Structure
Arachidonoyl Serinol
- CAS No.: 183718-70-9
- Formula:C23H39NO3
- Molecular Weight:377.56
IUPAC Name: (5Z,8Z,11Z,14Z)-N-(1,3-dihydroxypropan-2-yl)icosa-5,8,11,14-tetraenamide
InChIKey: QHELXIATGZYOIB-DOFZRALJSA-N
SMILES: O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NC(CO)CO
Biological Activity: Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [3H]2-oleoylglycerol and [3H]anandamide with IC50s of ～70 μM[1][2][3].
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Arachidonoyl Serinol | Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [3H]2-oleoylglycerol and [3H]anandamide with IC50s of ～70 μM. | |||||||||||||||||||||
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References
- [1]. Khanolkar AD, et, al. Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J Med Chem. 1996 Oct 25;39(22):4515-9. [Content Brief]
- [2]. Fowler CJ, et, al. Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. Biochem Pharmacol. 2005 Apr 15;69(8):1241-5. [Content Brief]
- [3]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84. [Content Brief]
Keywords
