(R)-Methanandamide
Based on 1 Customer Validation
(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors.
For research use only. We do not sell to patients.
- CAS No.: 157182-49-5
- Formula: C23H39NO2
- Molecular Weight:361.56
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CB1 20 nM (Ki) |
TRPV1 |
The endogenous cannabinoid (R)-Methanandamide exerts differential anti- and pronociceptive effects by activating both cannabinoid (CB1) and vanilloid (TRPV1) receptors of nociceptive primary afferents[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 157182-49-5
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Appearance Liquid
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Molecular Weight 361.56
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Formula C23H39NO2
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O
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Synonyms
AM-356
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (553.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (607 KB)
- English - EN (607 KB)
- Français - FR (607 KB)
- Deutsch - DE (607 KB)
- Norwegian - NO (607 KB)
- Español - ES (607 KB)
- Swedish - SV (607 KB)
- Italian - IT (607 KB)
- Korean - KR (607 KB)
- Portuguese - PT (607 KB)
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Handling Instructions (2659 KB)
References
[1]. V Abadji, et al. (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem. 1994 Jun 10;37(12):1889-93. [Content Brief]
[2]. M J M Fischer, et al. Cannabinoid and vanilloid effects of R(+)-methanandamide in the hemisected meningeal preparation. Cephalalgia. 2007 May;27(5):422-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7658 mL | 13.8290 mL | 27.6579 mL | 69.1448 mL |
| 5 mM | 0.5532 mL | 2.7658 mL | 5.5316 mL | 13.8290 mL | |
| 10 mM | 0.2766 mL | 1.3829 mL | 2.7658 mL | 6.9145 mL | |
| 15 mM | 0.1844 mL | 0.9219 mL | 1.8439 mL | 4.6097 mL | |
| 20 mM | 0.1383 mL | 0.6914 mL | 1.3829 mL | 3.4572 mL | |
| 25 mM | 0.1106 mL | 0.5532 mL | 1.1063 mL | 2.7658 mL | |
| 30 mM | 0.0922 mL | 0.4610 mL | 0.9219 mL | 2.3048 mL | |
| 40 mM | 0.0691 mL | 0.3457 mL | 0.6914 mL | 1.7286 mL | |
| 50 mM | 0.0553 mL | 0.2766 mL | 0.5532 mL | 1.3829 mL | |
| 60 mM | 0.0461 mL | 0.2305 mL | 0.4610 mL | 1.1524 mL | |
| 80 mM | 0.0346 mL | 0.1729 mL | 0.3457 mL | 0.8643 mL | |
| 100 mM | 0.0277 mL | 0.1383 mL | 0.2766 mL | 0.6914 mL |
(R)-Methanandamide Related Classifications
HY-101389 Related Classifications
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