19136-99-3
19136-99-3
Chemical Structure
Glutaric acid-d4
- CAS No.: 19136-99-3
- Formula:C5H4D4O4
- Molecular Weight:136.14
IUPAC Name: pentanedioic-2,2,4,4-d4 acid
InChIKey: JFCQEDHGNNZCLN-RRVWJQJTSA-N
SMILES: O=C(O)C([2H])([2H])CC([2H])([2H])C(O)=O
Biological Activity: Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glutaric acid-d4 | 98.0% | Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. | ||||||||||||||||||||
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Glutaric acid (Standard) | 98.78% | Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM. | ||||||||||||||||||||
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Glutaric acid-d2 | Glutaric acid-d2 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. | |||||||||||||||||||||
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Glutaric acid-d6 | 98.0% | Glutaric acid-d6 is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. | ||||||||||||||||||||
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Glutaric acid | 98.44% | Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. | ||||||||||||||||||||
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D-Glutamic acid-d5 | 99.91% | D-Glutamic acid-d5 is the deuterium labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods. | ||||||||||||||||||||
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Aminoadipic acid-d3 | 98.95% | Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid. Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine. | ||||||||||||||||||||
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Aminoadipic acid-d6 | Aminoadipic acid-d6 is deuterated labeled Aminoadipic acid (HY-113328). Aminoadipic acid is an intermediate in the metabolism of lysine and glycopurine. | |||||||||||||||||||||
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3-Methylglutaric acid-d4 | 3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid (HY-113410). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration. | |||||||||||||||||||||
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3-Hydroxyglutaric acid-d5 | 99.72% | 3-Hydroxyglutaric acid-d5 is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative. | ||||||||||||||||||||
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L-Glutamic acid-13C5,15N,d5 | 99.0% | L-Glutamic acid-13C5,15N,d5 is the deuterium, 13C-, and 15-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. | ||||||||||||||||||||
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L-Glutamic acid-d5 | 99.84% | L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. | ||||||||||||||||||||
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L-Glutamic acid-d3 | 99.12% | L-Glutamic acid-d3 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. | ||||||||||||||||||||
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Succinic acid (Standard) | 99.97% | Succinic acid (Standard) is the analytical standard of Succinic acid. This product is intended for research and analytical applications. Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields. | ||||||||||||||||||||
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Succinic acid-d4 | 99.91% | Succinic-2,2,3,3-d4 acid is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism. | ||||||||||||||||||||
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Succinic acid-13C4 | 99.7% | Succinic acid-13C4 is the 13C labeled Succinic acid. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries. | ||||||||||||||||||||
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Succinic acid-13C2 | 99.0% | Butanedioic acid-13C2 is the 13C labeled Succinic acid. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries. | ||||||||||||||||||||
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Succinic acid-13C2 | Succinic acid-13C2 is the 13C labeled Succinic acid. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries. | |||||||||||||||||||||
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2-Methylsuccinic acid-d6 | 2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy. | |||||||||||||||||||||
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Suberic acid | 98.0% | Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness. | ||||||||||||||||||||
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Suberic acid-d4 | 99.93% | Suberic acid-d4 (Octanedioic acid-d4) is the deuterated-labeled Suberic acid (HY-W015300). Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness. | ||||||||||||||||||||
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Adipic acid (Standard) | 99.29% | Adipic acid (Standard) (Hexanedioic acid (Standard)) is the analytical standard of Adipic acid (HY-W017522). This product is intended for research and analytical applications. Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-13C6 | 98.0% | Adipic acid-13C6 (Hexanedioic acid-13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-13C | 98.62% | Adipic acid-13C (Hexanedioic acid-13C) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-d8 | 99.65% | Adipic acid-d8 (Hexanedioic acid-d8) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-d44-1 | Adipic acid-d4-1 (Hexanedioic acid-d4-1) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | |||||||||||||||||||||
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Adipic acid-13C2 | Adipic acid-13C2 (Hexanedioic acid-13C2) is 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | |||||||||||||||||||||
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DL-Glutamic acid-d5 | 99.89% | DL-Glutamic acid-d5 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability. | ||||||||||||||||||||
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DL-Glutamic acid-d3 | 99.65% | DL-Glutamic acid-d3 is the d3-labeled DL-Glutamic acid (HY-W041895). DL-Glutamic acid is a racemic amino acid mixture and an antibacterial agent. DL-Glutamic acid reduces RNA and DNA levels, with a more significant effect on RNA. DL-Glutamic acid inhibits cell division of Rhodospirillum rubrum. | ||||||||||||||||||||
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3,3'-Azanediyldipropionic acid-d8 | 3,3'-Azanediyldipropionic acid-d8 is the deuterium labeled 3,3'-Azanediyldipropionic acid. | |||||||||||||||||||||
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Pimelic acid (Standard) | ≥98% | Pimelic acid (Standard) is the analytical standard of Pimelic acid. This product is intended for research and analytical applications. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research. | ||||||||||||||||||||
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Pimelic acid-d4 | Pimelic acid-d4 is the deuterium labeled Pimelic acid. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78. [Content Brief]
- [3]. Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101. [Content Brief]
