19198-75-5
Chemical Structure
Decyl gallate
- CAS No.: 19198-75-5
- Formula:C17H26O5
- Molecular Weight:310.39
InChIKey: AOTRKUOCGUXQCY-UHFFFAOYSA-N
SMILES: O=C(C1=CC(O)=C(C(O)=C1)O)OCCCCCCCCCC
Biological Activity: Decyl gallate is an antifungal (fungal) agent. Decyl gallate downregulates the expression of the pro-apoptotic (apoptosis) protein Bak, upregulates the expression of the anti-apoptotic protein Bcl-2, and inhibits DNA damage. Decyl gallate disrupts ALG12-mediated N-glycosylation, overactivates the UPR pathway, and simultaneously reduces fungal cell wall enzyme activity, chitin levels, mitochondrial activity, budding ability, cell viability, and host cell adhesion capacity. Decyl gallate reduces inflammatory responses induced by fungal infection and disrupts fungal membrane structure. Decyl gallate can be used in studies related to paracoccidioidomycosis and invasive fungal infections[1][2][3].
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Decyl gallate | Decyl gallate is an antifungal (fungal) agent. Decyl gallate downregulates the expression of the pro-apoptotic (apoptosis) protein Bak, upregulates the expression of the anti-apoptotic protein Bcl-2, and inhibits DNA damage. Decyl gallate disrupts ALG12-mediated N-glycosylation, overactivates the UPR pathway, and simultaneously reduces fungal cell wall enzyme activity, chitin levels, mitochondrial activity, budding ability, cell viability, and host cell adhesion capacity. Decyl gallate reduces inflammatory responses induced by fungal infection and disrupts fungal membrane structure. Decyl gallate can be used in studies related to paracoccidioidomycosis and invasive fungal infections. | |||||||||||||||||||||
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- [1]. Bernardi T, et al. Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43. Med Mycol. 2017;55(8):890-894. [Content Brief]
- [2]. de Paula E Silva ACA, et al. Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidioides lutzii. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e01909-18. [Content Brief]
- [3]. de Paula E Silva AC, et al. Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi. Evid Based Complement Alternat Med. 2014;2014:506273. [Content Brief]
Keywords
