194041-66-2
Chemical Structure
Sulfo-NHS-LC-LC-Biotin
Synonym(s): Biotin-XX-SSE
- CAS No.: 194041-66-2
- Formula:C26H40N5NaO10S2
- Molecular Weight:669.74
IUPAC Name: sodium 8-((2-aminoethyl)amino)naphthalene-1-sulfonate
InChIKey: PLZQFLFWCXFJDQ-BJPAGVOZSA-M
SMILES: O=C(C(CC1=O)S(=O)(O[Na])=O)N1OC(CCCCCNC(CCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)=O
Biological Activity: Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is used to label the proteins exposed to the external leaflet of intact exosomes and contains a larger spacer arm between the biotin and amine reactive linker. The size of this linker helps to overcome steric hindrance and increases labeling efficiency at the crowded exosome surface[1][2].
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Sulfo-NHS-LC-LC-Biotin | 99.3% | Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is used to label the proteins exposed to the external leaflet of intact exosomes and contains a larger spacer arm between the biotin and amine reactive linker. The size of this linker helps to overcome steric hindrance and increases labeling efficiency at the crowded exosome surface. | ||||||||||||||||||||
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- [1]. Diaz G, et al. Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection. Sci Rep. 2016 Nov 29;6:37975. [Content Brief]
- [2]. Gabant G, et al. Assessment of solvent residues accessibility using three Sulfo-NHS-biotin reagents in parallel: application to footprint changes of a methyltransferase upon binding its substrate. J Mass Spectrom. 2008 Mar;43(3):360-70. [Content Brief]
Keywords
