19902-91-1
19902-91-1
Chemical Structure
Dihydromethysticin
Synonym(s): (+)-Dihydromethysticin
- No. CAS: 19902-91-1
- Formula:C15H16O5
- Molecular Weight:276.29
IUPAC Name: (S)-6-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
InChIKey: RSIWXFIBHXYNFM-NSHDSACASA-N
SMILES: O=C1C=C(OC)C[C@H](CCC2=CC=C(OCO3)C3=C2)O1
Biological Activity: Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma[1][2][3][4][5].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Dihydromethysticin | 99.71% | Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma. | ||||||||||||||||||||
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Dihydromethysticin (Standard) | ≥98% | Dihydromethysticin (Standard) is the analytical standard of Dihydromethysticin (HY-N0921). This product is intended for research and analytical applications. Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma. | ||||||||||||||||||||
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(+)-Kavain | 99.10% | (+)-Kavain, a main kavalactone that can be extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied. | ||||||||||||||||||||
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Macelignan (Standard) | ≥98% | Macelignan (Standard) is the analytical standard of Macelignan. This product is intended for research and analytical applications. Macelignan ((+)-Anwulignan; Anwuligan) is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities. | ||||||||||||||||||||
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Dihydrokavain | 99.94% | Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects. | ||||||||||||||||||||
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Methysticin | Methysticin is a major kavalactone in kava extract to induce CYP1A1. | |||||||||||||||||||||
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erythro-Austrobailignan-6 | erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK. | |||||||||||||||||||||
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4,5-Dihydropiperlonguminine | 99.67% | 4,5-Dihydropiperlonguminine is a natural product that can be isolated from the seeds of Piper tuberculatum Jacq. (Piperaceae). 4,5-Dihydropiperlonguminine is a insecticide against velvetbean caterpillars. | ||||||||||||||||||||
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Piperanine | Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum. | |||||||||||||||||||||
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Methyl piperate | Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC503.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC5027.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to research mental disorders . | |||||||||||||||||||||
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Kavain | 99.89% | Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor. | ||||||||||||||||||||
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Methylsticin (Standard) | ≥98% | Methylsticin (Standard) is the analytical standard of Methylsticin. This product is intended for research and analytical applications. Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity. | ||||||||||||||||||||
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References
- [1]. Pan H, et al. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. Mol Carcinog. 2020 Jun;59(6):575-589. [Content Brief]
- [2]. Melchert PW, et al. In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. Chem Biol Interact. 2022 Apr 25;357:109883. [Content Brief]
- [3]. Narayanapillai SC, et al. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification. Drug Metab Dispos. 2016 Mar;44(3):422-7. [Content Brief]
- [4]. Hu Q, et al. Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. Chem Res Toxicol. 2020 Jul 20;33(7):1980-1988. [Content Brief]
