19902-91-1
Chemical Structure
Dihydromethysticin
Synonym(s): (+)-Dihydromethysticin
- CAS No.: 19902-91-1
- Formula:C15H16O5
- Molecular Weight:276.29
IUPAC Name: (S)-6-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
InChIKey: RSIWXFIBHXYNFM-NSHDSACASA-N
SMILES: O=C1C=C(OC)C[C@H](CCC2=CC=C(OCO3)C3=C2)O1
Biological Activity: Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dihydromethysticin | 99.71% | Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma. | ||||||||||||||||||||
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Dihydromethysticin (Standard) | ≥98% | Dihydromethysticin (Standard) is the analytical standard of Dihydromethysticin (HY-N0921). This product is intended for research and analytical applications. Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma. | ||||||||||||||||||||
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References
- [1]. Pan H, et al. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. Mol Carcinog. 2020 Jun;59(6):575-589. [Content Brief]
- [2]. Melchert PW, et al. In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. Chem Biol Interact. 2022 Apr 25;357:109883. [Content Brief]
- [3]. Narayanapillai SC, et al. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification. Drug Metab Dispos. 2016 Mar;44(3):422-7. [Content Brief]
- [4]. Hu Q, et al. Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. Chem Res Toxicol. 2020 Jul 20;33(7):1980-1988. [Content Brief]
