208237-49-4
208237-49-4
Chemical Structure
NK 314
- CAS No.: 208237-49-4
- Formula:C22H18ClNO4
- Molecular Weight:395.84
IUPAC Name: 1-hydroxy-2-methoxy-14,15-dihydro-13H-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]pyrrolo[1,2-f]phenanthridin-12-ium chloride
InChIKey: FXBDAIVJLCTTAW-UHFFFAOYSA-N
SMILES: OC1=C(C=CC2=C1C(CCC3)=[N+]3C4=C5C=C6OCOC6=CC5=CC=C24)OC.[Cl-]
Biological Activity: NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM[1].
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NK 314 | NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM. | |||||||||||||||||||||
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