2100864-57-9
2100864-57-9
Chemical Structure
CCB02
- CAS No.: 2100864-57-9
- Formula:C14H9N3O
- Molecular Weight:235.24
IUPAC Name: 3-methoxybenzo[b][1,6]naphthyridine-4-carbonitrile
InChIKey: QNJYUHRGCPRPQS-UHFFFAOYSA-N
SMILES: N#CC1=C(OC)N=CC2=CC3=CC=CC=C3N=C12
Biological Activity: CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CCB02 | 99.93% | CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1. | ||||||||||||||||||||
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References
Keywords
